In clinical studies :. If you experience digestive problems while taking Cymbalta, talk with your doctor. They may recommend treatment to relieve this side effect. Or they may have you try a different medication to treat your condition.
Some people may experience insomnia trouble sleeping while taking Cymbalta. With insomnia, you can have trouble falling asleep or staying asleep.
It can cause you to wake up too early. If you experience sleep issues while taking Cymbalta, talk with your doctor. They may suggest ways to manage this side effect. Headaches can occur while taking Cymbalta. Headache can also be a symptom of hyponatremia low sodium levels.
This is a serious side effect that can occur with Cymbalta. For this reason, call your doctor if you experience headache while taking Cymbalta. Your doctor can determine the cause of your headaches. They may also decide to have you try a different medication for your condition. Like other antidepressants, Cymbalta may raise your risk for suicidal thoughts and behaviors. Cymbalta has a boxed warning for this side effect. A boxed warning is the most serious warning from the FDA.
Clinical studies have shown antidepressants increase the risk of suicidal thoughts and behaviors in children and young adults ages 24 years or younger.
In people ages 65 and older, antidepressants can actually reduce the risk of suicidal thoughts and behaviors. During your treatment, you should watch closely for any new or sudden changes in your behavior, feelings, moods, or thoughts. Also ask your family members, caregivers, and healthcare providers to look for changes in your behavior or moods.
Call your doctor right away if you or someone else notices any changes. Typically, your doctor will start you on a low dosage. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. The recommended starting dose for treating depression in most adults is 40 mg 20 mg twice a day to 60 mg either 30 mg twice a day or 60 mg once a day per day.
Your doctor may decide to start you on 30 mg per day before increasing to a higher dosage, however. The maximum dosage of Cymbalta for treating depression in adults is mg per day. In adults younger than 65 years old, the recommended Cymbalta dosage for treating anxiety is 60 mg per day. Your doctor may decide to start you on 30 mg per day before increasing to this dose, however. This dose should be continued for 2 weeks.
The maximum dosage of Cymbalta for treating anxiety in adults of any age is mg per day. Diabetic neuropathy is a painful condition resulting from nerve damage in people with diabetes. For treating pain from diabetic neuropathy in adults, the recommended dose of Cymbalta is 60 mg once daily.
The recommended Cymbalta dosage for treating fibromyalgia in adults is 60 mg once daily. Then, assuming you respond well to the drug, your doctor will increase your dose to 60 mg once a day. Then, assuming you respond well to the drug, your doctor will increase your dose to 60 mg once daily. For treating GAD in children ages 7 to 17 years old, the recommended dosage of Cymbalta is 30 mg once a day.
This dose should be used for at least 2 weeks. For treating fibromyalgia in children ages 13 to 17 years old, the recommended Cymbalta dosage is 30 mg once a day. If you miss a dose of Cymbalta, take your missed dose as soon as you remember. This may raise your risk for side effects from the drug. This can include setting an alarm on your phone or downloading a reminder app.
A kitchen timer can work, too. Cymbalta is meant to be used as a long-term treatment. To help lower your risk for these symptoms, your doctor will gradually reduce your dosage over time.
This is known as a drug taper. If you have additional questions about your risk for withdrawal or dependence with Cymbalta, talk with your doctor. Cymbalta stays in your system for about 3 days. Cymbalta may also be used off-label for other conditions. With this condition, you may feel sadness, loss, or anger that interferes with your daily activities.
Clinical studies have shown Cymbalta to be effective for treating depression. One study compared daily use of Cymbalta with a placebo a treatment with no active drug. Almost everyone experiences anxiety at some point.
However, you may experience extreme feelings of anxiety, or anxiety that lasts longer than 6 months. If these feelings interfere with your daily life, you may have an anxiety disorder. People with GAD have excessive anxiety that can occur frequently. Symptoms of GAD may vary but can include:. One clinical study involved adults with GAD. Researchers first gave everyone Cymbalta for 26 weeks. People whose condition improved with the drug were then randomly chosen to either keep taking Cymbalta or switch to a placebo.
A placebo is a treatment with no active drug. They used increases in these scores to determine when someone in the study had a GAD relapse. The researchers compared how long it took for people using Cymbalta to have a GAD relapse compared with people taking a placebo. These results show that people taking Cymbalta had reduced anxiety symptoms for a longer period of time than people who took a placebo. Cymbalta is FDA-approved to treat pain from diabetic neuropathy nerve damage.
Diabetic neuropathy is a common condition in people with type 1 and type 2 diabetes. People with diabetes have high levels of glucose sugar in their blood. Over time, having increased glucose levels can cause nerve damage.
Symptoms of diabetic neuropathy include numbness, pain, tingling, or weakness in your hands or feet. Clinical studies have shown Cymbalta to be effective for treating pain from diabetic neuropathy. Researchers in one study randomly assigned adults with diabetic nerve pain to take either Cymbalta or a placebo every day for 12 weeks. They assessed pain again after the study to compare how Cymbalta and a placebo affected pain. Cymbalta is FDA-approved to treat fibromyalgia.
This is a chronic condition that can cause:. Fibromyalgia is often misdiagnosed and can be difficult to treat. Clinical studies have shown Cymbalta to be effective at treating fibromyalgia. One study compared Cymbalta with a placebo in adults with fibromyalgia.
Before the study, these adults had an average pain score of 6. People in the study took either Cymbalta or a placebo every day for 6 months.
The researchers then measured their pain scores again to see if there was any improvement. Cymbalta is FDA-approved to treat chronic musculoskeletal pain. This refers to pain in the bones, muscles, ligaments, nerves, and tendons. Chronic pain is pain that lasts for more than 3 to 6 months. Clinical studies have shown Cymbalta to be effective for treating chronic musculoskeletal pain.
These studies involved adults with chronic low back pain or chronic pain caused by osteoarthritis a joint disorder that causes swelling and pain. In one study , adults with chronic low back pain took either Cymbalta or a placebo every day for 13 weeks. Before the study, people rated their pain on a scale of 0 no pain to 10 worst pain possible. The researchers had people rate their pain again at the end of the study.
Clinical studies have shown Cymbalta to be effective for treating these conditions in children. Cymbalta belongs to a class of medications known as serotonin-norepinephrine reuptake inhibitors SNRIs.
It affects your levels of both serotonin and norepinephrine. SSRIs, on the other hand, only affect your serotonin levels. Controlled substances are medications that could cause either physical or mental dependence. With dependence , your body needs the drug to feel normal. The Drug Enforcement Administration DEA sets limits on who can make, possess, and use medications that are controlled substances. However, Cymbalta could cause withdrawal symptoms if you stop taking the drug suddenly.
Addiction is different from dependence. Over time, someone with addiction needs more and more of a drug to feel its effects. This is because the drug affects your central nervous system CNS. If you have questions or concerns about your risk for dependence with Cymbalta, talk with your doctor. Cymbalta is approved to treat mood disorders, such as depression and anxiety.
Because it affects your mood, some people report feeling calm or as if their mood is boosted while taking the drug.
If you have questions about how Cymbalta may affect you, talk with your doctor or pharmacist. This was one of the more common side effects of the drug in clinical studies.
In the studies:. If you have questions about side effects from Cymbalta, talk with your doctor or pharmacist. You may wonder how Cymbalta compares with other medications that are prescribed for similar uses. Here we look at how Cymbalta and Lexapro are alike and different. Lexapro contains the active drug escitalopram. Lexapro belongs to a class of medications called selective serotonin reuptake inhibitors SSRIs.
Both types of drugs are commonly used as antidepressants. Cymbalta comes as capsule that you take by mouth. Cymbalta and Lexapro have some similar side effects and others that vary. Below are examples of these side effects. This list contains 10 of the most common mild side effects that can occur with both Cymbalta and Lexapro when taken individually :.
These lists contain examples of serious side effects that can occur with Cymbalta, with Lexapro, or with both drugs when taken individually. The use of Cymbalta and Lexapro in treating depression in adults has been compared in a meta-analysis. A meta-analysis is a type of study that looks at the results of numerous clinical studies to see if there are any consistent results across the studies. Increased heart rate, irregular menstrual cycle, increased frequency of urination or difficulty urinating, increased liver enzymes, teeth grinding, low sodium symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering , angle closure glaucoma symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye , serotonin syndrome symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death , hypertensive crisis severely elevated blood pressure , myocardial infarction heart attack , Stevens-Johnson Syndrome rash , pancreatitis SNRI antidepressants, including duloxetine, may increase the risk of bleeding events.
Combined use of aspirin, nonsteroidal anti-inflammatory drugs e. This may include gums that bleed more easily, nose bleed, or gastrointestinal bleeding. Some cases have been life threatening. To date, there are no known problems associated with long term use of duloxetine. It is a safe and effective medication when used as directed.
Duloxetine should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors MAOIs. Sleep, energy, or appetite may show some improvement within the first weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.
Depressed mood and lack of interest in activities may need up to weeks to fully improve. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo.
Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults age 65 and older taking antidepressants have a decreased risk of suicidality. Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice.
This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein.
Search Close Menu. Sign In About Mental Illness. About Mental Illness Treatments. About Mental Illness Research. Your Journey Individuals with Mental Illness. Your Journey Family Members and Caregivers. Your Journey Identity and Cultural Dimensions. Your Journey Frontline Professionals. Get Involved Become a Fundraiser.
Some medicines and duloxetine can interfere with each other and increase the chances of you having side effects. Do not take the herbal remedy St John's wort while you're being treated with duloxetine, as this will increase your risk of side effects. Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements. Duloxetine is a type of antidepressant known as a serotonin-noradrenaline reuptake inhibitor SNRI.
SNRIs are thought to work by increasing the amount of mood-enhancing chemicals serotonin and noradrenaline in the brain. You may see an improvement after 2 to 4 weeks. Improvements for nerve pain may take longer. Do not stop taking duloxetine after a week or two just because you feel it's not helping your symptoms. Antidepressants like duloxetine help to gradually lift your mood so you feel better. You may notice that you sleep better and get on with people more easily because you're less anxious.
Do not expect to feel better overnight, though. Some people feel worse during the first few weeks of treatment before they begin to feel better. If you're taking it for nerve pain or urinary incontinence, you may also notice some of these feelings.
For depression or anxiety - once you're feeling better, it's likely that you'll continue to take duloxetine for several more months.
Most doctors recommend that you take antidepressants for 6 months to a year after you no longer feel depressed or anxious. Stopping your medicine too soon can make depression and anxiety come back.
For nerve pain or urinary incontinence - if duloxetine is helping your symptoms, you can continue taking it long term. Your doctor may check that you're still having relief from the pain or urinary incontinence every few months.
If you have been feeling better for 6 months or more, your doctor may suggest coming off duloxetine. Your doctor will probably recommend reducing your dose gradually over several weeks, or longer if you have been taking duloxetine for a long time. This is to help prevent any extra side effects you might get as a reaction to coming off the medicine. Do not stop taking duloxetine suddenly or without talking to your doctor first.
Taking antidepressants, including duloxetine, is just one of many ways to treat depression and anxiety. If duloxetine is not working for you, speak to your doctor - there may be other treatments you can try. If you start to have problems with your weight while taking duloxetine, talk to your doctor or pharmacist.
During the first few days of taking duloxetine, it might be best to stop drinking alcohol until you see how the medicine affects you. There's no firm evidence to suggest that taking duloxetine will reduce fertility in either men or women. But speak to a pharmacist or your doctor before taking it if you're trying to get pregnant. Speak to your doctor if you're planning to get pregnant while taking duloxetine.
Duloxetine will not affect any type of contraception, including the combined pill or emergency contraception. Some people cannot concentrate properly while they're taking duloxetine. When you first start taking duloxetine, it's a good idea to stop driving and cycling, and avoid using machines or tools, for the first few days until you know how this medicine makes you feel.
Cannabis can affect the levels of duloxetine and make you more likely to get side effects. Talk to your doctor if you think you might use recreational drugs while taking duloxetine. Page last reviewed: 31 January Next review due: 31 January Duloxetine On this page About duloxetine Key facts Who can and can't take it How and when to take it Side effects How to cope with side effects Pregnancy and breastfeeding Cautions with other medicines Common questions.
About duloxetine Duloxetine is an antidepressant medicine. Duloxetine comes as capsules and is only available on prescription. Help us improve our website Can you answer a quick question about your visit today? Duloxetine normally takes 2 to 4 weeks to work. It may take longer if you're taking it for nerve pain. Common side effects include feeling sick, a dry mouth, headache, constipation and feeling sleepy.
These side effects are usually mild and go away after a couple of weeks. If you and your doctor decide to take you off duloxetine, your doctor may recommend reducing your dose gradually to help prevent extra side effects.
Duloxetine is also called by the brand names Cymbalta and Yentreve. Duloxetine can be taken by adults aged 18 years and over. For stress urinary incontenince, duloxetine can only be used by women.
0コメント